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Urolithin A powder can induce mitophagy, clear the abnormal accumulation of mitochondria in hematopoietic stem cells caused by aging, restore the blood reconstruction function of hematopoietic stem cells, and improve immunity.
Urolithin A is produced naturally through intestinal flora metabolism of foods rich in ellagitannins. The most famous of these foods include pomegranates, nuts, strawberries, and raspberries. Eating more of them is beneficial.
| ANALYSIS | SPECIFICATION | RESULTS |
| Purity | ≥98%(HPLC) | 98.34% |
| Physical Characteristics | ||
| Appearance | Yellowish Powder | Conforms |
| Loss on drying | ≤5g/100g | 5g/100g |
| Residue on Ignition | ≤1g/100g | 1g/100g |
| Heavy Metals | ||
| Heavy metals | ≤10ppm | Conforms |
| Lead | ≤2ppm | Conforms |
| Arsenic | ≤2ppm | Conforms |
| Mercury | ≤1ppm | Conforms |
| Microbiological Tests | ||
| Total Plate Count | ≤1000cfu/g | 1000cfu/g |
| Total Yeast & Mold | ≤100cfu/g | 100cfu/g |
| E.Coli | Negative/10g | Negative |
| Salmonella | Negative/10g | Negative |
| Staphylococcus | Negative/10g | Negative |
We cannot obtain urolithin A powder directly from food, but we can supplement its precursor ellagitannin.
Common foods rich in ellagic acid and ellagitannins include: pomegranates, raspberries, blueberries, blackberries, walnuts, pistachios, pecans, etc., as well as some teas and aged wines and spirits.
Among them, blackberries and blueberries, which have relatively low sugar content, are more ketogenic, and nuts are also good.
Moreover, it is not only the raw materials that determine the bioavailability of urolithin A, but also the composition of the intestinal flora. It is currently difficult to determine which bacterial groups are useful, and the results are unknown.
However, one study found that the Mediterranean diet increased urolithin A production and had a different gut microbiome compared to the regular diet group.
1. Lose Weight
Urolithin A activates brown fat in the body, which is responsible for burning calories. Brown fat can be called an alien type of fat, but it falls asleep after the adolescent development period. Urolithin A can stimulate it to wake up and become active, burning more calories for the body, thereby reducing weight.
2. Activate Mitophagy
The protection of urolithin A powder against muscle loss was only recently discovered, and previous research on it focused on mitochondria, especially mitophagy.
UA can activate mitophagy through multiple pathways, such as activating enzymes that promote mitophagy, regulating the mitophagy pathway, and promoting the formation of autophagosomes. With age and some age-related diseases, mitophagy will decline or even stagnate, and organ function will slowly decline.
3. Anti-inflammatory
The anti-inflammatory effect of UA is multifaceted. First of all, it exists in large amounts in the intestines, so it is most effective in inflammatory bowel diseases. Including acute enteritis, ulcerative colitis, and even colon cancer.
Secondly, UA not only protects against intestinal inflammation because it reduces the overall serum levels of inflammatory factors. Theoretically, UA can act on diseases caused by inflammation.
Therefore, when UA exerts anti-inflammatory effects in the brain, it can improve many neurodegenerative diseases, including Alzheimer's disease (AD), memory impairment, and stroke.
4. Antioxidant Properties
Urolithin A powder also has a powerful effect, that is, it can improve oxidative stress. It can not only remove free radicals, inhibit oxidase enzymes, but also enhance cellular antioxidant sources. Those beneficial health properties are due to UA's antioxidant capabilities.
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